Too expensive
For the price I expected more quality. I agree with everything that was said in Quentin S.'s comment.
The backplate looks very cheap, it couldn't have cost them more than 2 cents, and the alignment with the USB ports is rough.
The location of the SATA ports is poorly thought out and the OC features are limited. For example the BIOS offers 3 modes: normal, performance, or extreme, but none of these modes have any impact on the performance management of your hardware. They are disabled on the Prime series (confirmed by an ASUS representative).
If I had to do it all over again, I would go for a gaming version, TUF or go back to MSI.